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KMID : 0123420080130010091
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Korean Journal of Community Nutrition
2008 Volume.13 No. 1 p.91 ~ p.99
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Relationship between Ferric Reducing Antioxidant Power and Metabolic Risk Factors in Korean Women Living in Seoul
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Kwak Ho-Kyung
Lee Mee-Sook
Lim So-Young
Yoon Sun
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Abstract
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The present study was conducted to examine metabolic risk factors and total antioxidant capacity (TAC) of Korean
females living in Seoul and to investigate the relationship between the metabolic risk factors and serum TAC. A total
of 353 females aged between 20 and 64 participated in the study. Obesity indicators, blood pressure, serum lipid
profile and fasting blood glucose were measured as metabolic risk factors. Ferric reducing antioxidant power (FRAP)
assay was employed to determine serum TAC of subjects. Obesity indicators such as body mass index, waist
circumference and waist-hip ratio were significantly higher in the participants aged ≥ 50 y (older group) than in the
participants aged 20-49 y (younger group) (p < 0.001). Blood pressure, serum total cholesterol (TC), triglyceride (TG)
and fasting blood glucose were also significantly higher in the older group than in the younger group (p < 0.001),
demonstrating significant positive correlations between age and MS risk factors. The association between FRAP and
MS risk factors were also investigated. FRAP values showed significant positive correlations with age (p = 0.001),
serum TG (p = 0.002) and TC (p = 0.03). A tendency of positive association between FRAP and waist circumference
was observed without any significant difference (p = 0.06). Increased serum FRAP with central obesity and serum
lipids may be interpreted as results of activation of antioxidant defense system against oxidative stress induced by
metabolic syndrome (MS) constituent factors. However, to verify the function of FRAP as a potential biomarker of
susceptibility to MS various contributors to the plasma antioxidant capacity and their biological relevance related to
MS should be elucidated further. (Korean J Community Nutrition 13(1) : 91~99, 2008)
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KEYWORD
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ferric reducing antioxidant power, ·metabolic syndrome, ·obesity, ·cholesterol, ·triglyceride
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